| Plasma | Serum |
| The cell-free part of blood, that has been treated with anti-coagulants. | The liquid part of blood after coagulation, therefore, devoid of clotting factors as fibrinogen. |
| It is liquid. | It is fluid. |
| Makes up about 55% of overall blood volume. | Serum = Plasma – Clotting factor |
| Obtain before the coagulation. | Obtain after the coagulation. |
| Waste removal | Achieved by centrifugation. |
| Contains fibrinogen and albumin | |
| Albumin: keep fluid in bloodstream and prevent leakage | |
| Fibrinogen: normal clotting of blood. Fibrinogen—>fibrin—->clot forms on blood. |
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